Maria Margarida Catalão Almiro e Castro


This group focuses on the interaction of metal ions with biological systems regarding their essentiality and toxic effects as well as the development of metal-based drugs for therapy and diagnostics. Studies have been focused on the role of essential metal elements, the targets and mechanisms of toxic elements, the development of metal based drugs for therapy, diagnostic and multimodal agents for theranostics. The methodologies followed are mostly based on characterization of the metal based agents using spectroscopic techniques (UV-vis, fluorescence, EPR, relaxometry and NMR), complemented with in vitro, ex vivo and in vivo studies.