Selected Publications

Piotr Gierlich; Ana I. Mata; Claire Donohoe; Rui M. M. Brito; Mathias O. Senge; Lígia C. Gomes-da-Silva. "Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment". Molecules 25 22 (2020): 5317-5317. DOI: 10.3390/molecules25225317

Zaida L. Almeida; Rui M. M. Brito. "Structure and Aggregation Mechanisms in Amyloids". Molecules 25 5 (2020): 1195-1195. DOI: 10.3390/molecules25051195

Nícia Rosário-Ferreira; António J. Preto; Rita Melo; Irina S. Moreira; Rui M. M. Brito. "The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection". International Journal of Molecular Sciences (2020). DOI: 10.3390/ijms21041511

Frangolho, Ana; Correia, Bruno E.; Vaz, Daniela C.; Almeida, Zaida L.; Brito, Rui M. M.. "Oligomerization Profile of Human Transthyretin Variants with Distinct Amyloidogenicity". (2020). DOI: 10.3390/molecules25235698

Adão, Regina; Cruz, Pedro F.; Vaz, Daniela C.; Fonseca, Fátima; Pedersen, Jannik Nedergaard; Ferreira-da-Silva, Frederico; Brito, Rui M. M.; et al. "DIBMA nanodiscs keep a-synuclein folded". (2020). DOI: 10.1016/j.bbamem.2020.183314

Matti Knaapila; Beverly Stewart; Vasil M. Garamus; M. Luísa Ramos; Pedro F. Cruz; Rui M. M. Brito; Lícinia L. G. Justino; et al. "Poly(9-undecyl-9-methyl-fluorene) and poly(9-pentadecyl-9-methyl-fluorene): Synthesis, solution structure, and effect of side chain asymmetry on aggregation behavior". Journal of Polymer Science Part B: Polymer Physics 57 13 (2019): 826-837. DOI: 10.1002/polb.24838

Bezerra, F., Simões, C.J.V., Beirão, J.M., Saraiva, M.J., Brito, R.M.M. and Almeida, M.R. (2019). Targeting transthyretin amyloidosis in the eye with next-generation stabilizers: AT40 displays potent TTR stabilization in the human vitreous. Amyloid, 26(sup1), pp.73–74. DOI: 10.1080/13506129.2019.1583193

Simões CJV, Almeida ZL, Cardoso AL, Bezerra F, Almeida MR, Beirão J, Pinho E Melo TMVD, Saraiva MJ, Brito RMM. (2019). Lead optimization of resilient next-generation transthyretin stabilizers for multiple target-product profiles: approaching the CNS. Amyloid. 26(sup1):77-78. DOI: 10.1080/13506129.2019.1583195

Trigueiro-Louro JM, Correia V, Santos LA, Guedes RC, Brito RMM, Rebelo-de-Andrade H. (2019). To hit or not to hit: Large-scale sequence analysis and structure characterization of influenza A NS1 unlocks new antiviral target potential. Virology. 535:297-307. DOI: 10.1016/j.virol.2019.04.009

Jesus CSH, Cruz PF, Arnaut LG, Brito RMM, Serpa C.J (2018). One Peptide Reveals the Two Faces of α-Helix Unfolding-Folding Dynamics. Phys Chem B. 122(14):3790-3800. DOI: 10.1021/acs.jpcb.8b00229

Jorge, M., Garrido, N.M., Simões, C.J.V., Silva, C.G., Brito, R.M.M. (2017) "Predicting hydrophobic solvation by molecular simulation: 1. Testing united-atom alkane models", ‎J. Comput. Chem. 38(6), pp. 346–358. DOI: 10.1002/jcc.24690

Jesus, C.S.H., Almeida, Z.L., Vaz, D.C., Faria, T.Q., Brito, R.M.M. (2016) "A New Folding Kinetic Mechanism for Human Transthyretin and the Influence of the Amyloidogenic V30M Mutation". DOI: 10.3390/ijms17091428

Silva, C.G., Simões, C.J.V., Carreiras, P., Brito, R.M.M. (2016) "Enhancing Scoring Performance of Docking-Based Virtual Screening Through Machine Learning". Current Bioinformatics 11 (4), pp. 408-420. DOI: 10.2174/1574893611666160212234816

Chaves, O.A., Jesus, C.S.H., Cruz, P.F., Sant'Anna, C.M., Brito, R.M.M., Serpa, C. (2016) "Evaluation by fluorescence, STD-NMR, docking and semi-empirical calculations of the o-NBA photo-acid interaction with BSA". Spectrochim Acta A Mol Biomol Spectrosc. 169, pp. 175-181 DOI: 10.1016/j.saa.2016.06.028

Vilaça, H., Pereira, G., Castro,  T.G., Hermenegildo, B.F., Shi, J., Faria, T.Q., Micaêlo, N., R.M.M. Brito, Xu, B., Castanheira, E.M.S., Martins, J.A., Ferreira, P.M.T. (2015). "New self-assembled supramolecular hydrogels based on dehydropeptides". J. Mater. Chem. B 3, pp. 6355-6367. DOI. 10.1039/C5TB00501A

Faria, T.Q., Almeida,  Z.L.,  Cruz, P.C.,  Jesus, C.S.H., Castanheira, P.,  Brito, R.M.M. (2015). "A look into amyloid formation by transthyretin: aggregation pathway and a novel kinetic model". Phys. Chem. Chem. Phys. 17, pp. 7255-7263 DOI: 10.1039/C4CP04549A

Mompeán, M., Buratti, E., Guarnaccia, C., Brito, R.M.M., Chakrabartty, A., Baralle, F.E., Laurents, D.V. (2014). "Structural characterization of the minimal segment of TDP-43 competent for aggregation", Archives of Biochemistry and Biophysics 545, pp. 53–62. DOI: 10.1016/j.abb.2014.01.007

Jesus, C.S.H., Vaz, D.C., Saraiva, M.J.M., and Brito, R.M.M. (2013). "The V30M amyloidogenic mutation decreases the rate of refolding kinetics of the tetrameric protein transthyretin", Advances in Biomedical Spectroscopy, vol. 7, pg. 267-271 DOI: 10.1155/2012/502497 

Camacho, R., Pereira, M., Costa, V.S., Fonseca, N.A., Adriano, C., Simões, C.J.V., and Brito, R.M.M. (2011). "A relational learning approach to structure-activity relationships in drug design toxicity studies", J. Integrative Bioinformatics 8(3): 182. DOI: 10.2390/biecoll-jib-2011-182

Henriques, E.S, Brito, R.M.M., Soares, H., Ventura, S., de Oliveira, V.L., Parkhouse, R.M.E. (2011) "Modeling of the Toll-like receptor 3 and a putative Toll-like receptor 3 antagonist encoded by the African swine fever virus", Protein Sci. 20(2), pp. 247-255. DOI: 10.1002/pro.554

Simões, C.J.V., Mukherjee, T., Brito R.M.M., Jackson, R.M. (2010) "Toward the Discovery of Functional Transthyretin Amyloid Inhibitors: Application of Virtual Screening Methods", J. Chem. Inf. Model. 50(10), pp. 1806-1820. DOI: 10.1021/ci100250z

Swain, M., Silva, C.G., Loureiro-Ferreira, N., Ostropytskyy, V., Brito, J., Stahl, F., Riche, O., Dubitzky, W., Brito, R.M.M. (2010) "P-found: grid-enabling distributed repositories of protein folding and unfolding simulations for data mining, Futur. Gener. Comp. Syst. 26 (3), pp. 424-433. DOI: 10.1016/j.future.2009.08.008

Rodrigues, J.R., Simões, C.J.V., Silva, C.G., Brito, R.M.M. (2010) "Potentially amyloidogenic conformational intermediates populate the unfolding landscape of transthyretin: insights from molecular dynamics simulations", Protein Sci. 19(2), pp. 202-219. DOI: 10.1002/pro.289

Fernandes, E., Jorge, A.M., Silva, C.G., Brito, R.M.M. (2008) "A knowledge discovery method for the characterization of protein unfolding processes", Advances in Soft Computing, vol. 49, pp. 180-188. DOI: 10.1007/978-3-540-85861-4_22

Correia, B.E., Loureiro-Ferreira, N., Rodrigues, J.R., Brito, R.M.M. (2006) "A structural model of an amyloid protofilament of transthyretin", Protein Sci. 15(1), pp. 28-32. DOI: 10.1110/ps.051787106

Azevedo, P.J., Silva, C.G, Rodrigues, J.R., Loureiro-Ferreira, N., Brito, R.M.M. (2005) "Detection of Hydrophobic Clusters in Molecular Dynamics Protein Unfolding Simulations Using Association Rules", Lecture Notes in Computer Sciences, vol. 3725, pp. 329-337. DOI: 10.1007/11573067_33

Berrar, D., Stahl, F., Silva, C.G., Brito, R.M.M, Dubitzky, W. (2005) "Towards data warehousing, mining of protein unfolding simulation data",  J. Clin. Monit. Comput. 15(4-5), pp. 307-317. DOI: 10.1007/s10877-005-0676-z