Papers in International Scientific Periodicals with Referees 

• Chiral Hydroxymethyl-1H,3H-pyrrolo[1,2-c]thiazoles: the Search for Selective p53-Activating Agents for Colorectal Cancer Therapy, M. M. Hendrikx, A. M. R. Pereira, A. B. Pereira, C. S. C. Carvalho, J. L. P. Ribeiro, M. I. L. Soares, L. Saraiva,* T. M. V. D. Pinho e Melo* RSC Med. Chem. 2024,15, 1652-1663. 
• On the mechanochemical synthesis of C-scorpionates with an oxime moiety and their application in the  copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. C. Gomes, M. Costa, S. M. M. Lopes, B. A. Nogueira, R. Fausto, J. A. Paixão, T. M. V. D. Pinho e Melo, L. M. D. R. S. Martins,  M. Pineiro*, New J. Chem. 2024, 48, 874-886.
• Novel Foscan®‑derived ring‑fused chlorins for photodynamic therapy of cancer, A. I. Mata, N. A. M. Pereira, A. L. Cardoso, B. F. O. Nascimento, M. Pineiro, F. A. Schaberle, L. C. Gomes‑da‑Silva, R. M. M. Brito, T. M. V. D. Pinho e Melo, Bioorg. Med.l Chem. 2023, 93, 117443.
• Organocatalysts for the asymmetric Neber reaction: synthesis of chiral 2-(tetrazol-5-yl)-2H-azirines, C. Alves, T. J. Sase, C. Gadelho, D. Murtinho, M. E. S. Serra, A. L. Cardoso, T. M. V. D. Pinho e Melo, ChemistrySelect 2023, 8, e20230281.
• The role of the solvent and concentration on the properties of oxime bearing A2B corroles, A. C. B. Rodrigues, S. M. M. Lopes, C. Cunha, J. Braz, T.M. V. D. Pinho e Melo, J. S. Seixas de Melo, M.Pineiro, Phys. Chem. Chem. Phys. 2023, 25, 10263-10277.
• Oxidized cholesteryl ester induces exocytosis of dysfunctional lysosomes in lipidotic macrophages, N. Domingues,* A. R. A. Marques,* R. D. A. Calado, I. S. Ferreira, C.Ramos, J. Ramalho, M. I. L. Soares, T. Pereira, L. Oliveira, J. R. Vicente, L.H. Wong, I. C. M. Simões, T. M. V. D. Pinho e Melo, A. Peden, C. G. Almeida, C. E. Futter, R. Puertollano, W. L.C. Vaz, O. V. Vieira*, Traffic, 2023, 24, 284-307.
• Reactivity of ethyl nitrosoacrylate toward pyrrole, indole and pyrrolo[3,2-c]carbazole: an experimental and theoretical study, A. Benzi, S. M. M. Lopes, S. C. C. Nunes, G.Giorgi, L. Bianchi, C. Tavani, A. A. C. C. Pais, G.Petrillo, T. M. V. D. Pinho e Melo, Front. Chem. 2023, 11:1229669.
• Diazo-coupled porous organic polymers as efficient catalysts for metal-free Henry and Knoevenagel reactions, Machado, T. F.; Valente, A. J. M.; Serra, M. E. S.; Murtinho, D., Microporous Mesoporous Mater. 2023, 112561.
• Reduced chitosan as a strategy for removing copper ions from water, Matias, P. M. C.; Sousa, J. F. M.; Bernardino, E. F.; Vareda, J. P.; Durães, L.; Abreu, P. E.; Marques, J. M. C.; Murtinho, D.; Valente, A. J. M., Molecules 2023, 28, 4110.
• Continuous flow enantioselective processes catalysed by cinchona alkaloid derivatives, E. P. Carreiro, G. J. Hermann, A. J. Burke, H.- J. Federsel, Tetrahedron Green Chem. 2023, 2, 100025.
• Practical design of 3,6-di-tert-butyl-diphenyldibenzofulvene derivatives with enhanced aggregation-induced emission, C. Cunha, M. Peixoto, J. Santos, P. Abreu, J. Paixão, M. Pineiro, J. Seixas de Melo, ACS Appl. Opt. Mat. 2023, 1, 1, 340–353.
• Ring-fused meso-tetraarylchlorins as auspicious PDT sensitizers: synthesis, structural characterization, photophysics and biological evaluation, Laranjo, M., Pereira, N. A. M., Oliveira, A. S. R., Aguiar, M. C., Brites, G., Nascimento, B. F. O., B. Serambeque, B., Costa, B. D. P., Pina, J., Seixas de Melo, J. S., Pineiro, M., Botelho, M. F., Pinho e Melo, T. M. V. D., Front. Chem. 2022, 10, 873245.
• Insights into the anticancer activity of chiral alkylidene-β-lactams and alkylidene-γ-lactams: synthesis and biological investigation, Alves, A. J. S., Alves, N. G., Laranjo, M., Gomes, C. S. B., Gonçalves, A. C., Sarmento-Ribeiro, A. B., Botelho, M. F., Pinho e Melo, T. M. V. D., Bioorg Med. Chem. 2022, 63, 116738.
• Portrayal of the color polymorphism in the 5-acetyl-derivative of ROY, Nogueira, B. A, Carvalho, M., Paixão, J. A., Eusébio, M. E., Lopes, Lopes, S. M. M., Pinho e Melo, T. M. V. D., Fausto, R., CrystEngComm 2022, 24, 1459-1474.
• Unveiling a family of spiro-b-lactams with anti-HIV and anti-plasmodial activity via phosphine-catalyzed [3+2] annulation of 6-alkylidene-penicillanates and allenoates, Alves, A. J. S., Alves, N. G., Bártolo, I., Fontinha, D., Caetano, S., Prudêncio, M., Taveira, N., Pinho e Melo, T. M. V. D., Front. Chem. 2022, 10, 1017250.
• Differential tunneling-driven and vibrationally-induced reactivity in isomeric benzazirines, Nunes, C. M., Doddipatla, S., Loureiro, G. F., Roque, J. P. L., Pereira, N. M. A., Pinho e Melo, T. M. V. D., Fausto, R., Chem. Eur. J. 2022, e202202306.
• High instantaneous inhibitory potential of bictegravir and the new spiro-β-lactam BSS-730A for HIV-2 isolates from RAL- naïve and RAL-failing patients, Bártolo, I., Moranguinho, I., Gonçalves, P., Diniz, A. R., Borrego, P., Martin, F., Figueiredo, I., Gomes, P., Gonçalves, F., Alves, A. J. S., Alves, N. G., Caixas, U., Pinto, I. V., Barahona, I., Pinho e Melo, T. M. V. D., Taveira, N., Int. J. Mol. Sci. 2022, 23, 14300.
• 3-(1,2,3-Triazol-4-yl)-β-carbolines and 3-(1H-tetrazol-5-yl)-β-carbolines: synthesis and evaluation as anticancer agents, Ribeiro, J. L. P., Loureiro, J. B., Lopes, S. M. M., Saraiva, L., Pinho e Melo, T. M. V. D., Pharmaceuticals 2022, 15, 1510. [Special issue “State-of-the-art of Medicinal Chemistry in Portugal”]
• Deciphering the mechanism behind efficient enantioselective ethylation with thiazolidine-based amino alcohols, Tavares, N. C. T., Cacho, V. R. G., Costa, D. C. S., Nunes, S. C. C., Pais, A. A. C. C., Murtinho, D., Serra, M. E. S., Appl Organomet Chem 2022, 36, e6567.
• β-Ketoenamine covalent organic frameworks—effects of functionalization on pollutant adsorption, Machado, T. F., Santos, F. A., Pereira, R. F. P., Bermudez, V. Z., Valente, A. J. M., Serra, M. E. S., Murtinho, D., Polymers 2022, 14, 3096.
• Tryptanthrin and its derivatives in drug discovery: synthetic insights, Brandão, P., Pineiro, M., Burke, A. J., Synthesis 2022, 54, 4235-4245.
• Immobilization of functionalized epi-Cinchonine organocatalysts on controlled porous glass-beads: applications in batch and continuous flow, Amorim, A. C., Fonseca, D. P., Carreiro, E. P., Hermann, G. J., Federsel, H. J., Burke, A. J, Synlett 2022, 33, 1756-1762.
• Synthesis of β-cyclodextrin-based nanosponges for remediation of 2,4-D polluted waters, Valente, A. J. M., Pirozzi, D., Cinquegrana, A., Utzeri, G., Murtinho, D., Sannino, F., Environ. Res. 2022, 215, 114214.
• Cyclodextrin-based nanosponges: overview and opportunities,Utzeri, G., Matias, P. M. C., Murtinho, D., Valente, A. J. M., Front. Chem. 2022, 10, 1–25.
• Micro-/nanofibrillated cellulose-based coating formulations: a solution for improving paper printing quality, Sharma, M., Aguado, R., Murtinho, D., Valente, A.J.M., Ferreira, P.J.T., Nanomaterials 2022, 12, 1–18.
• Novel fluorinated ring-fused chlorins as promising PDT agents against melanoma and esophagus cancer, N. A. M. Pereira, M. Laranjo, B. F. O. Nascimento, J. C. S. Simões, J. Pina, B. D. P. Costa, G. Brites, J. Braz, J. S. Seixas de Melo, M. Piñeiro, M. F. Botelho, T.M. V. D. Pinho e Melo, RSC Med. Chem. 2021, 12, 615-627.
• Inducing Bond-Breaking/Bond-Forming Reactions by Infrared Vibrational Excitation of a Remote Antenna, C. M. Nunes, N. A. M. Pereira, L. P. Viegas, T. M. V. D. Pinho e Melo, R. Fausto, Chem. Commun. 2021, 57, 9570-9573.
• Novel spiro-β-lactam BSS-730A displays potent anti-HIV and anti-plasmodial activity, I. Bártolo, B. S. Santos, D. Fontinha, M. Machado, D. Francisco, B.Sepodes, J.Rocha, H. Mota-Filipe, R. Pinto, M. E.Figueira, H. Barroso, T. Nascimento, A. P. A. de Matos, A. J. S. Alves, N. G. Alves, C.J.V. Simões, M. Prudêncio, T, M.V.D. Pinho e Melo,* Nuno Taveira,* ACS Infect. Dis. 2021, 7, 421-434.
• Switching on H-tunneling through conformational control, J. P. L. Roque, C. M. Nunes, L. P. Viegas, N. A. M. Pereira, T. M. D. V. Pinho e Melo, P. R. Schreiner, R. Fausto, J. Am. Chem. Soc.  2021, 143, 8266-8271.
• Strategies and methodologies for the construction of spiro-γ-lactams: an update, A. J. S. Alves, N. G. Alves, M. I. L. Soares, T. M. V. D. Pinho e Melo, Organic Chemistry Frontiers 2021, 8, 3543-3593.
• (3S,4S)‐N‐substituted‐3,4‐dihydroxypyrrolidines as ligands for the enantioselective Henry reaction, M. R. R. Rénio, F. J. P. M. Sousa, N. C.T. Tavares, A. J. M. Valente, M. E. S. Serra, D. Murtinho, Appl Organomet Chem. 2021, e6175.
• Synthesis and Structure-Activity Relationships of New Chiral Spiro-β-lactams Highly Active Against HIV-1 and Plasmodium, N. G. Alves, I. Bártolo, A. J.S. Alves, D. Fontinha, D. Francisco, S. M.M. Lopes, M. I.L. Soares, C. J.V. Simões, M. Prudêncio, N. Taveira, T. M.V.D. Pinho e Melo, Eur. J. Med. Chem. 2021, 219, 113439.
• Recent Advances in the Synthesis of Spiro-β-Lactams and Spiro-δ-Lactams, N. G. Alves, A. J. S. Alves, M.I. L. Soares, T.M. V. D. Pinho e Melo, Advanced Synthesis & Catalysis 2021, 363, 2464-2601.

• Covalent Organic Frameworks: Synthesis, Properties and Applications—An Overview, T. F. Machado, M. E. S. Serra, D. Murtinho, A. J. M. Valente, M. Naushad, Polymers 2021, 13(6), 970 .
• A New Selective P53 Activator and Anticancer Agent to Improve Colorectal Cancer Therapy, H. Ramos, M. I. Soares, J. Silva, L. Raimundo, C. Gomes, F. Reis, F. Monteiro, C.Nunes, S. Reis, B. Bosco, S. Piazza, L. Domingues, P. Chlapek, R. Veselska, A. Inga, T. M.V.D. Pinho e Melo,* L. Saraiva*, Cell Reports 2021, 35, 108982.
• Association of antioxidant monophenolic compounds with β-cyclodextrin-functionalized cellulose and starch substrates, R. Aguado, D. Murtinho, A. J. M. Valente, Carbohydrate Polymers 2021, 267, 118189.
• Reactivity of Steroidal 1-Azadienes Toward Enamines: An Approach to Novel Chiral Penta- and Hexacyclic Steroids, S. M. M. Lopes, J. R. C. Santos, T. M. V. D. Pinho e Melo, Org. Biomol. Chem. 2021,19, 1122-1132.
• Mini-review: Synthetic methods for the production of cationic sugar-based surfactants, C. F. Jesus, A. A. S. Alves, S. M. Fiuza, D. Murtinho, F. E. Antunes, Journal of Molecular Liquids 2021, 342, 117389.
• Novel approach on the synthesis of starch betainate by transesterification, M. Sharma, R. Aguado, D. Murtinho, A. J. M. Valente, P. J. T. Ferreira, International Journal of Biological Macromolecules 2021, 182, 1681.
• One-pot Synthetic Approach to Dipyrromethanes and Bis(indolyl)methanes via Nitrosoalkene Chemistry, A. L. Cardoso, S. M. M. Lopes, C. Grosso, M. Pineiro, A. Lemos, T. M. V. D. Pinho e Melo, J. Chem. Educ. 2021, 98, 2661-2666.
• Spiro-Lactams as Novel Antimicrobial Agents,Alves, A. J. S. Alves, N. G., Caratão, C. C., Esteves, M. I. M., Fontinha, D., Bártolo, I., Soares, M. I. L., Lopes, S. M. M., Prudêncio, M., Taveira, N., Pinho e Melo, T. M. V. D., Curr. Top. Med. Chem. 2020, 20, 140-152.
• Meso-Substituted Corroles from Nitrosoalkenes and Dipyrromethanes, Lopes, S. M. M., Pinho e Melo, T. M. V. D., J. Org. Chem. 2020, 85 (5), 3328-3335.
• I2/NaH/DMF as Oxidant Trio for the Synthesis of Tryptanthrin from Indigo or Isatin, Brandão, P., Pinheiro, D., Seixas de Melo, J. S., Pineiro, M., Dyes and Pigments 2020, 173, 107935-107939.
• Platinum(II) Ring-Fused Chlorins as Efficient Theranostic Agents: Dyes for Tumor-Imaging and Photodynamic Therapy of Cancer, Laranjo, M., Aguiar, M. C., Pereira, N. A., Brites, G., Nascimento, B. F., Brito, A. J., Casalta-Lopes, Gonçalves, A. C., Sarmento-Ribeiro, A. B., Pineiro, M.  Botelho, M. F., Pinho e Melo, T. M. V. D., Eur. J. Med. Chem. 2020, 200, 112468.
• Chiral Thiazolidine based Organocatalysts: Synthesis and Application in Asymmetric Aldol Reactions, Félix, A. R. G., Simões, P. R. D., Sousa, F. J. P. M., Serra, M. E. S., Murtinho, D., Lett. Org. Chem. 2020, 17, 372–380.
• Advanced Mechanochemistry Device for Sustainable Synthetic Processes, Gomes, C.  Vinagreiro, C. , Damas, L., Aquino, G., Quaresma, J., Chaves, C., Pimenta, J., Campos, J., Pereira, M., Pineiro, M. ACS Omega 2020, 5, 10868–10877.
• Synthesis, Characterization and Evaluation of the Antibacterial and Antitumor Activity of HalogenatedSalen Copper (II) Complexes derived from Camphoric Acid, Pires, A. S., Batista, J., Murtinho, D., Nogueira, C., Karamysheva, A., Ramos, M. L. , Milne, B.F., Tavares, N.T., Gonçalves, A.C., Abrantes, A.M., Soares, R., Gonçalves, T., Botelho, M. F., Serra, M.E.S., Appl. Organomet. Chem. 2020, 34, e5569.
• Synthesis of Novel ChiralSpiroisoxazolidine-b-Lactams from 6-Alkylidenepenicillanates: A 1,3-Dipolar Cycloaddition Approach, Alves, A. J. S., Pinho e Melo, T. M. V. D., Eur. J. Org. Chem. 2020, 6259-6269.
• A review on Cationic Starch and Nanocellulose as Paper Coating Components, Sharma, M., Aguado, R., Murtinho, D., Valente, A. J. M., Mendes De Sousa, A. P., Ferreira, P. J. T., Int. J. Biol. Macromol. 2020, 162, 578–598.
• Asymmetric Neber Reaction in the Synthesis of Chiral 2-(Tetrazol-5-yl)-2H-Azirines, Alves, C., Grosso, C., Barrulas, P., Paixão, J. A., Cardoso, A. L., Burke, A. J., Lemos, A., Pinho e Melo, T. M. V. D., Synlett 2020, 31(06), 553-558.
• Uncommon Sorption Mechanism of Aromatic Compounds onto Poly(Vinyl Alcohol)/Chitosan/Maleic Anhydride-β-Cyclodextrin Hydrogels, Filho, C. M. C., Bueno, P. V. A., Matsushita, A. F. Y., Vilsinski, B. H., Rubira, A. F., Muniz, E. C., Murtinho, D. M. B., Valente, A. J. M., Polymers 2020, 12, 877.
• Ring-fused diphenylchlorins as potent photosensitizers for PDT applications: in vitro tumour cell biology and in vivo chick embryo CAM studies, Nascimento, B. F. O, Laranjo, M., Pereira, N. A. M., Ferreira, J. D., Piñeiro, M., Botelho, M. F., Pinho e Melo, T. M. V. D., ACS Omega 2019, 4, 17244-17250.
• A broad overview on innovative functionalized paper solutions, Aguado, R., Murtinho, D., Valente, A. J. M., Nordic Pulp & Paper Research Journal 2019, 34 (4), 395-416.
• Natural Deep Eutectic Solvents in the Hetero-Diels-Alder Approach to Bis(indolyl)methanes, Grosso, C., Brigas, A., de los Santos, J. M., Palacios, F., Lemos, A., Pinho e Melo, T. M. V. D., Monatshefte für Chemie - Chemical Monthly  2019, 150, 1275-1288.
• New 3-Tetrazolyl-β-Carbolines and β-Carboline-3-Carboxylates with Anti-Cancer Activity,Panice, M. R. P., Lopes, S. M. M., Figueiredo, M. C., Ruiz, A. L. T. G., Foglio, M. A., Sarragiotto, M. H., Pinho e Melo, T. M. V. D., Eur. J. Med. Chem. 2019, 179, 123-132.
• Porphyrin synthesis using mechanochemistry: sustainability assessment, Gomes, C., Peixoto, M., Pineiro, M., J. Porphyr. Phthalocyan. 2019, 23, 889-897.
• Phosphane-catalyzed [3+2] Annulation of Allenoates with 3-Nitro-2H-chromenes: Synthesis of Cyclopenta[c]chromenes, Soares, M. I. L., Gomes, C. S. B., Nunes, S. C. C., Pais, A. A. C. C., Pinho e Melo, T. M. V. D., Eur. J. Org. Chem. 2019, 5441-5451.
• Tetrahydropyrazolo[1,5-a]pyridine-fused steroids and their in vitro biological evaluation in prostate cancer, Jorda, R. Lopes, S. M. M., Řezníčková, E., Ajani, H., Pereira, A. V., Gomes, C. S. B., Pinho e Melo, T. M. V. D., Eur. J. Med. Chem. 2019, 178, 168-176.
• Reactivity of Steroidal 1-Azadienes Toward Carbonyl Compounds under Enamine Catalysis: Chiral Penta- and Hexacyclic Steroids, Susana M. M. Lopes, Clara S. B. Gomes, Teresa M. V. D. Pinho e Melo, Org. Lett. 2018, 20, 4332-4336. 
• Combining Cellulose and Cyclodextrins: Fascinating Designs for Materials and Pharmaceutics, Cova T. F., Murtinho D., Pais A. A. C. C., Valente A. J. M, Frontiers in Chemistry 2018, 6, 271.
• Advances on Photodynamic Therapy of Melanoma through Novel Ring-Fused 5,15-Diphenylchlorins, N. A. M. Pereira, M. Laranjo, J. Pina, Andreia S. R. Oliveira, João Dias Ferreira, C. Sánchez-Sánchez, João Casalta-Lopes, Ana Cristina Gonçalves, Ana Bela Sarmento-Ribeiro, Marta Piñeiro, J. Sérgio Seixas de Melo, Maria Filomena Botelho and Teresa M. V. D. Pinho e Melo, Eur. J. Med. Chem. 2018, 146, 395-408.
• Thioindigo, and sulfonated thioindigo derivatives as solvent polarity dependent fluorescent on-off systems, Ricardo C. Pereira, Marta Pineiro, Adelino M. Galvão, J. Sérgio Seixas de Melo, Dye and Pigments, 2018, 158, 259-266.
• Dual Rh-Ru Catalysts for Reductive Hydroformilation of olefins to Alcohols, F. M. S. Rodrigues, P. K. Kucmierczyk, M. Pineiro, R. Jackstell, R. Franke, M. M. Pereira, M. Beller, ChemSusChem 2018, 11, 2310-2314.
• Platinum(II) Ring-fused Chlorins as Near-Infrared Emitting Oxygen Sensors and  Photodynamic Agents, N. A. M. Pereira, M. Laranjo, J. Casalta-Lopes, A.C. Serra, M. Piñeiro, J. Pina, J. S. Seixas de Melo, M. O. Senge, M. F. Botelho, L. Martelo, H. D. Burrows, T. M. V. D. Pinho e Melo, ACS Med. Chem. Lett. 2017, 8, 310−315.
• Molecular Dynamics of Cyclodextrins in Water Solutions from NMR Deuterium Relaxation: Implications for Cyclodextrin Aggregation, A. J. M. Valente, R. A. Carvalho, D. Murtinho, O. Söderman, Langmuir 2017, 33, 8233-8238.
• Enantioselective alkylation of aromatic aldehydes with (+)-camphoric acid derived chiral 1,3-diamine ligands, M. E. S. Serra, D. Murtinho, V. Paz, Tetrahedron: Asymmetry 2017, 28, 381-386.
• Dibrominated camphoric acid derived salen complexes: Synthesis, characterization and cytotoxic activity, M. E. S. Serra, D. Murtinho, Z. N. Rocha, A. S. Pires, J. G. Baptista, A. M. Abrantes, M. Laranjo, J. E. Casalta-Lopes, M. F. Botelho, A. A.C.C. Pais, S. C.C. Nunes, H. D. Burrows, T. Costa, Polyhedron 2017, 147-156.
• D-Penicillamine and L-Cysteine Derived Thiazolidine Catalysts: An Efficient Approach to Both Enantiomers of Secondary Alcohols, M. E. S. Serra, D. Costa, D. Murtinho, N. C. T. Tavares, T. M. V. D. Pinho e Melo, Tetrahedron, 72 2016,  5923-5927.
• 1H-Tetrazol-5-yl)-Allenes: Building Blocks for Tetrazolyl-Heterocycles, A. L. Cardoso, M.S. C. Henriques, J. A. Paixão, T. M. V. D. Pinho e Melo, J. Org. Chem. 2016, 81, 9028-9036.
• Bis-furans as novel transthyretin stabilizers and amyloid inhibitors, C. J. V. Simões, Z. L. Almeida, D. Costa, C. S. Jesus, A. L. Cardoso, M. R. Almeida, M. J. Saraiva, T.M. V. D. Pinho e Melo, R.M. M. Brito, Eur. J. Med. Chem. 2016, 121, 823-840.
• Reactions of Nitrosoalkenes with Dipyrromethanes and Pyrroles: Insight into the Mechanistic Pathway, S. C. C. Nunes, S.M. M. Lopes, C. S. B. Gomes, A. Lemos, A. A. C. C. Pais, T. M. V. D. Pinho e Melo, J. Org. Chem. 2014, 79, 10456−10465.
• Selective Synthesis of Tetra-substituted 4-(Tetrazol-5-yl)-1H-Imidazoles from 2-(Tetrazol-5-yl)-2H-Azirines, A. L. Cardoso, A. Lemos, T. M. V. D. Pinho e Melo, Eur. J. Org. Chem. 2014, 5159-5165. - Cover Picture
• On-water Synthesis of Dipyrromethanes via bis-Hetero-Diels-Alder Reaction of Azo- and Nitosoalkenes with Pyrrole, N. A. M. Pereira, S. M. M. Lopes, A. Lemos, T. M. V. D. Pinho e Melo, Synlett 2014, 25, 423-427.
• The Neber Approach to 2-(Tetrazol-5-yl)-2H-Azirines, Ana Lúcia Cardoso, Lourdes Gimeno, A. Lemos, F. Palacios, T. M. V. D. Pinho e Melo, J. Org. Chem. 2013, 78, 6983-6991.
• Synthesis of chiral spirocyclopentenyl-β-lactams via phosphane-catalyzed [3+2] annulation of allenoates with 6-alkylidenepenicillanates, B. S. Santos, T. M. V. D. Pinho e Melo, Eur. J. Org. Chem. 2013, 3901-3909. 
• Thiazolo[3,4-b]indazole-2,2-dioxides as Masked Extended Dipoles: Pericyclic Reactions of Benzodiazafulvenium Methides, M. I. L. Soares, C. M. Nunes, C. S. B. Gomes, T. M. V. D. Pinho e Melo, J. Org. Chem. 2013, 78, 628-637. 
• Aziridines in formal [3+2] cycloadditions: synthesis of five-membered heterocycles, A. L. Cardoso, T.M. V. D. Pinho e Melo, Eur. J. Org. Chem. 2012, 6479-6501.

Patents and Provisional Patent Application

• PT 102623 (B) (31/10/2003). Processo para a preparação de 1,1-dióxidos de ácidos penicilânicos e de intermediários di-halogenados (Process for the Preparation of 1,1-dioxypenicillanic acids and their dihalogenated intermediates, Patente Portuguesa). Inventors: António M. d'A. Rocha Gonsalves, Teresa M. V. D. Pinho e Melo, Ana L. Cardoso, J. P. Cardoso, J. J. P. Queiroga, Dália M. Barbosa. Titular: CIPAN - Companhia Industrial Produtora de Antibióticos, S.A. https://pt.espacenet.com/publicationDetails/biblio?FT=D&date=20031031&DB=&locale=pt_PT&CC=PT&NR=102623B&KC=B&ND=4

• PT 102622 (B) (31/10/2003). Processo para a preparação de 1,1-dióxidos de ácidos penicilânicos e de intermediários halogenados (Process for the Preparation of 1,1-dioxypenicillanic acids and their halogenated intermediates, Patente Portuguesa).  Inventors: António M. d'A. Rocha Gonsalves, Teresa M. V. D. Pinho e Melo, Ana L. Cardoso, J. P. Cardoso, J. J. P. Queiroga, Dália M. Barbosa. Titular: CIPAN - Companhia Industrial Produtora de Antibióticos, S.A. -https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20031031&DB=EPODOC&locale=pt_pt&CC=PT&NR=102622B&KC=B&ND=6

• WO2017145092) PLATINUM(II) RING-FUSED CHLORINS, METHODS AND USES THEREOF, Pub. No.: WO/2017/145092; International Application No.: PCT/IB2017/051045; Publication Date: 31.08.2017; International Filing Date: 23.02.2017; Publication Kind: A1; Inventors: Hugh Douglas Burrows, Teresa Margarida Vasconcelos Dias de Pinho e Melo, Arménio Coimbra Serra, Nelson António Melo Pereira, Liliana Marques Martelo, Marta Piñeiro Gómez,  João Sérgio Seixas de Melo, João Manuel Ferreira Pita Batista Pina, Maria Filomena Baça Roque, Botelho, Ana Margarida Coelho Abrantes, Mafalda Laranjo. Applicants: UNIV DE COIMBRA [PT];
• EP3419977 (A1); Publication Date: 02.01.2019 [https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2017145092&redirectedID=true]

• PT 109182 A (2017/08/24) - CLORINAS FUNDIDAS DE PLATINA(II), SEUS MÉTODOS E USOS; Inventors: Hugh Douglas Burrows, Teresa Margarida Vasconcelos Dias de Pinho e Melo, Arménio Coimbra Serra, Nelson António Melo Pereira, Liliana Marques Martelo, Marta Piñeiro Gómez, João sérgio Seixas de Melo, João Manuel Ferreira Pita Batista Pina, Maria Filomena Baça Roque, Botelho, Ana Margarida Coelho Abrantes, Mafalda Laranjo. BOLETIM DA PROPRIEDADE INDUSTRIALNo 2017/08/24 (164/2017), 24 de agosto de 2017- Página 7.(http://www.marcasepatentes.pt/files/collections/pt_PT/49/55/606/628/2017-08-24.pdf)

• (WO2016080853) 2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF;Publication Date: 26.05.2016; Publication Kind: A1; Biocant Park Parque Tecnologico de Cantanhede Nucleo 04; Lote 2; sala 2.11 3060-197; Cantanhede (PT); Inventors: Rui Manuel Pontes Meireles Ferreira de Brito, Carlos José Vieira Simões, Teresa Margarida Vasconcelos Dias de Pinho e Melo, Bruno Lourenço da Silva Victor, Zaida Catarina Lourenço de Almeida, Ana Lúcia Cabral Lopes, Bruno Filipe Oliveira Nascimento, Maria Silvia Vieira Pereira Ferreira. Applicants: BSIM2 – BIOMOLECULAR SIMULATIONS LDA [PT]; [https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016080853]
• US20190092737 B2, 2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF. Inventors: Rui Manuel Pontes Meireles Ferreira de Brito, Carlos José Vieira Simões,Teresa Margarida Vasconcelos Dias de Pinho e Melo, Bruno Lourenço da Silva Victor, Zaida Catarina Lourenço de Almeida, Ana Lúcia Cabral Lopes, Bruno Filipe Oliveira Nascimento, Maria Silvia Vieira Pereira Ferreira (Grant Date: 2021) - Publication Kind:B2
• 2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF - US20220267286 A2 (2022); US 11,584,727 B2 (2023)  [https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016080853]

• WO2016203402) BIS-FURAN DERIVATIVES AS TRANSTHYRETIN (TTR) STABILIZERS AND AMYLOID INHIBITORS FOR THE TREATMENT OF FAMILIAL AMYLOID POLYNEUROPATHY (FAP);Publication Date: 22.12.2016; Publication Kind: A1;Inventors: Carlos José Vieira Simões, Zaida Catarina Lourenço de Almeida, Teresa Margarida Vasconcelos Dias de Pinho e Melo, Rui Manuel Pontes Meireles Ferreira de Brito, Dora Cristina Silva Costa, Ana Lúcia Cabral Lopes. Applicants: BSIM2 – BIOMOLECULAR SIMULATIONS LDA [PT]; 
• US 20180208570 B2 - United States Patent - BIS-FURAN DERIVATIVES AS TRANSTHYRETIN (TTR) STABILIZERS AND AMYLOID INHIBITORS FOR THE TREATMENT OF FAMILIAL AMYLOID POLYNEUROPATHY (FAP); Date of Patent: Aug. 13, 2019; Assignee: BSIM Therapeutics, S. A. Coimbra (PT);
• EP 3.307.723.B1 - European Patent - BIS-FURAN DERIVATIVES AS TRANSTHYRETIN (TTR) STABILIZERS AND AMYLOID INHIBITORS FOR THE TREATMENT OF FAMILIAL AMYLOID POLYNEUROPATHY (FAP);  Date of Patent: Nov. 11, 2020; Assignee: BSIM Therapeutics, S. A. Coimbra (PT) [https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016203402].

• (WO/2018/207165) NOVEL SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF - Pub. No.: WO/2018/207165; International Application No.: PCT/IB2018/053357; Publication Date: 15.11.2018;International Filing Date: 14.05.2018; Publication Kind: A1; Applicants: UNIVERSIDADE DE COIMBRA [PT/PT]; Paço Das Escolas 3004-531 Coimbra, PT; FACULDADE DE FARMÁCIA DA UNIVERSIDADE DE LISBOA [PT/PT]; Av. Professor Gama Pinto 1649-003 Lisboa, PT; EGAS MONIZ - COOPERATIVA DE ENSINO SUPERIOR, CRL [PT/PT]; Campus Universitário, Quinta Da Granja, Monte De Caparica 2829-511 Caparica, PT;INSTITUTO DE MEDICINA MOLECULAR [PT/PT]; Av. Prof. Egas Moniz | Ed. Egas Moniz 1649-028 Lisboa, PT; Inventors:  VASCONCELOS DIAS DE PINHO E MELO, Teresa Margarida; C. SUZANO SANTOS, Bruna; BÁRTOLO, Inês; PRUDÊNCIO PIGNATELLI, Rui Miguel; MOURA DOS SANTOS DA COSTA TAVEIRA, Nuno Eduardo.
• EP3625238 (A1) - NOVEL SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF; Publication Date: 25.03.2020;
• US20200352916 (A1) - NOVEL SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF (2020); Publication Date12.11.20
• US 11,666,559 B2 - SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF; Date of Patent: June 6, 2023
• US2023/0285366 (A1), NOVEL SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF, Publication Date: 09/14/2023
• [https://patentscope.wipo.int/search/en/detail.jsf?docId=WO18207165&tab=PCTBIBLIO&maxRec=1000]  
• PT 110070 A (2018/11(12) - Novos Compostos Espiro-Lactâmicos, Processo e seus Usos; Inventors: Teresa Margarida Vasconcelos Dias de Pinho e Melo, Bruna C. Suzano Santos, Rui Miguel Prudêncio Pibnatelli, Inês Bártolo, Nuno Eduardo Moura dos Santos da Costa Taveira. BOLETIM DA PROPRIEDADE INDUSTRIAL, Nº 217/2018 (12/11/2018).

• (WO/2019/243906) Title: (EN) (3S)- AND (3R)-6,7-BIS(HYDROXYMETHYL)-1H,3H-PYRROLO[1,2-C]THIAZOLES AS P53 ACTIVATORS; (FR) (3S)- ET (3R)-6,7-BIS (HYDROXYMÉTHYL)-1H,3H-PYRROLO[1,2-C]THIAZOLES UTILISÉS COMME ACTIVATEURS DE P53Publication Number: WO/2018/207165; Publication Date: 26.12.2019; International Application No.: PCT/IB2019/053603; International Filing Date: 02.05.2019; Publication Kind: A1Applicants: UNIVERSIDADE DO PORTO, Praça Gomes Teixeira, S/N, 4º, S.419, 4099-002 Porto, PT; UNIVERSIDADE DE COIMBRA, Paço Das Escola 3004-531 Coimbra, PT; Inventors:  ATAÍDE SARAIVA, Lucília Helena, GAMA SOARES, Joana Oliveira; VASCONCELOS DIAS DE PINHO E MELO, Teresa Margarida; LOPES SOARES, Maria Isabel; NOGUEIRA RAMOS ROCHA, Helena Isabel.
• EP2019730929 (A1) (3S)- AND (3R)-6,7-BIS(HYDROXYMETHYL)-1H,3H-PYRROLO[1,2-C]THIAZOLES AS P53 ACTIVATORS; Publication: EP3810278A1·2021-04-28.
• US2021315866A1 - (3S)- AND (3R)-6,7-BIS(HYDROXYMETHYL)-1H,3H-PYRROLO[1,2-C]THIAZOLES AS P53 ACTIVATORS; Publication: 2021-10-14
• (https://worldwide.espacenet.com/patent/search/family/066867587/publication/EP3810278A1?q=pn%3DWO2019243906A1)

• Complexos poliméricos de lantanídeos luminescentes e matrizes de fibras celulósicas funcionalizadas para detecção de contrafação. Pedido provisório Patente Portuguesa 20201000011960. Inventors: A.J.M. Valente, A.A.C.C. Pais, D.M.B. Murtinho, A.F.Y. Matsushita, M.P.R.T. Faro. Requerentes: Raiz e Universidade de Coimbra.