Patricia O. Ferreira, Amanda C. Almeida, Giovanna de P. Costa, Carolina Torquetti, João A. Baptista, M.Ermelinda S. Eusébio, Flavio J. Caires, Ricardo A.E. Castro (2023). Norfloxacin cocrystals: mechanochemical synthesis and scale-up viability through solubility studies, Journal of Pharmaceutical Sciences.

DOI: 10.1016/j.xphs.2023.03.003


Joana F. C. Silva, Mário T. S. Rosado, Teresa M. R. Maria, Pedro S. Pereira Silva, Manuela Ramos Silva, Manuela Ramos Silva, M. Ermelinda S. Eusébio (2023). Introduction to Pharmaceutical Co-amorphous Systems Using a Green Co-milling Technique, J. Chem. Educ.



Mirosław Gałązka, Małgorzata Jasiurkowska-Delaporte, M. Ermelinda S. Eusébio, Mário T. S. Rosado4, Ewa Juszyńska-Gałązka5, Ewa Dryzek (2023). Study on molecular dynamics and phase transitions in 1,2-cyclohexanediol and 1,3-cyclohexanediol isomers by calorimetry and dielectric spectroscopy, Journal of Molecular Liquids.

DOI: 10.1016/j.molliq.2022.120874


Bruno Ekawa, Hermínio P. Diogo, Ricardo A. E. Castro, Flávio J. Caires, M. Ermelinda S. Eusébio (2023). Coamorphous systems of valsartan: Thermal Analysis contribution to evaluate intermolecular interactions effects on the structural relaxation, Molecules.

DOI: 10.3390/molecules28176240


Joana F.C.Silva, Mário T.S.Rosado, M.  Ermelinda S.Eusébio (2021). Structure and energetics of intermolecular association in two lurasidone co-amorphous drug systems, Journal of Molecular Structure.

DOI: 10.1016/j.molstruc.2021.130709


Santos, J. A. V., Baptista, J. A., Santos, I. C., Maria, T., Canotilho, J., & Castro, R., Eusébio, M. E. S. (2021). Pharmaceutical nanococrystal synthesis: a novel grinding approcah. CrystEngComm.

DOI: 10.1039/D1CE00407G


Baptista, J.A.; Rosado, M.T.S.; Castro, R.A.E.; Évora, A.O.L.; Maria, T.M.R.; Ramos Silva, M.; Canotilho, J.; Eusébio, M.E.S. (2021) Dihydrofolate Reductase Inhibitors: The Pharmacophore as a Guide for Co-Crystal Screening. Molecules.

DOI: 10.3390/molecules26216721


Baptista, J. A., Castro, R. A. E., Rosado, M. T. S., Maria, T. M. R., Silva, M. R., Canotilho, J., & Eusébio, M. E. S. (2021). Polymorphic Cocrystals of the Antimalarial Drug Pyrimethamine: Two Case Studies. Crystal Growth & Design.

DOI: 10.1021/acs.cgd.1c00005


Baptista, J. A., Eusébio, M. E. S., & Pereira, M. M. (2021). New renewable raw materials for thermal energy storage. Journal of Thermal Analysis and Calorimetry, 145(1), 27-37.

DOI: 10.1007/s10973-020-09685-w


Ciciliati, M. A., Eusébio, M. E. S., Silva, M. R., Cavalheiro, É. T. G., & Castro, R. A. E. (2019). Metoprolol: solid forms of a top selling antihypertensive. CrystEngComm, 21(29), 4319-4328.

DOI: 10.1039/C9CE00700H


Évora, A. O. L., Castro, R. A. E., Maria, T. M. R., Ramos Silva, M., Canotilho, J., & Eusébio, M. E. S. (2019). Lamotrigine: Design and synthesis of new multicomponent solid forms. European Journal of Pharmaceutical Sciences, 129, 148-162.

DOI: 10.1016/j.ejps.2019.01.007


Holanda, B. B. C., Bannach, G., Ramos Silva, M., Eusébio, M. E. S., & Castro, R. A. E. (2019). Polymorphism of gemfibrozil: Investigation by thermal and spectroscopic methods. Thermochimica Acta, 675, 113-118.

DOI: 10.1016/j.tca.2019.03.026


Maria, T. M. R., Rosado, M. T. S., Oliveira, M. F., Bebiano, S. S., Castro, R. A. E., Juszyńska-Gałązka, E., . . . Eusébio, M. E. S. (2019). Polymorphism of 1,3-cyclohexanediols: molecular structure and plastic crystal formation of cyclohexanediol isomers. CrystEngComm, 21(22), 3395-3408.

DOI: 10.1039/C9CE00186G


Silva, J. F. C., Rosado, M. T. S., Jasiurkowska-Delaporte, M., Silva, M. R., Piedade, M. F. M., Dryzek, E., & Eusébio, M. E. S. (2019). Ordered and Plastic Crystals in the Complex Polymorphism of Pinanediol. Crystal Growth & Design, 19(11), 6127-6135.

DOI: 10.1021/acs.cgd.9b00428


Machado, S.M.T., Castro, R.A.E., Maria, T.M.R., Canotilho, J., Eusébio, M.E.S. (2017), Levetiracetam + nonsteroidal anti-inflammatory drug binary systems: a contribution to the development of new solid dosage forms, Int. J. Pharm., 533, pp. 1-13.

DOI: 10.1016/j.ijpharm.2017.09.012


Maria, T.M.R., Marins, F.A., Costa, J.B.S., Ramos Silva, M. Carrilho, R.M.B., Monteiro, C.J.P., Pereira, M.M., Eusébio, M.E.S., (2017) Solid state investigation of BINOL and BINOL derivatives: A contribution to enantioselective symmetry breaking by crystallization, Thermochim. Acta, 648, pp. 32-43.

DOI: 10.1016/j.tca.2016.12.008


Cortesão, A.M., Henriques, J.G., Castro, R.A.E., Maria, T.M.R., Canotilho, J., Eusébio, M. E.S., (2017) Binary phase diagrams of pyridinecarboxamide isomers, J. Therm. Anal. Calorim., 130, pp. 1727–1733.

DOI: 10.1007/s10973-017-6474-2


Nogueira, B.A., Ildiz, G.O., Canotilho, J., Eusébio, M.E.S., Henriques, M.S.C., Paixão, J.A., Fausto, R., (2017) 5-Methylhydantoin: From Isolated Molecules in a Low-Temperature Argon Matrix to Solid State Polymorphs Characterization, J. Phys. Chem. A, 121, pp. 5267-5279.

DOI: 10.1021/acs.jpca.7b05030


Viel, Q., Brandel, C., Cartigny, Y., Eusébio, M.E.S., Canotilho, J., Dupray, V., Dargent, E., Coquerel, G., Petit, S., (2017) Crystallization from the Amorphous State of a Pharmaceutical Compound: Impact of Chirality and Chemical Purity, Cryst. Growth Des., 17, pp. 337-346.

DOI: 10.1021/acs.cgd.6b01566


Susano, M.T., Martín-Ramos, P., Maria, T.M.R., Folkersma, S., Pereira, L.C.J., Ramos Silva, M., (2017) Co-crystal of suberic acid and 1,2-bis(4-pyridyl)ethane: A new case of packing polymorphism, J. Mol. Struct., 1147, pp, 76-83.

DOI: 10.1016/j.molstruc.2017.06.043


Martín-Ramos, P., Maria, T.M.R., Guimaraes, A.C., Carrión-Prieto, P., Hernández-Navarro, S., Martín-Gil, J., (2017) Crude and refined oils from Elaeis guineensis: Facile characterization by FTIR and thermal analysis techniques, Int. J. Food Prop., 20S3, pp. S2739-S2749.

DOI: 10.1080/10942912.2017.1372470


Perpétuo, G.L., Chierice, G.O., Ferreira, L.T., Fraga-Silva, T.F.C., Venturini, J., Arruda, M.S.P., Bannach, G., Castro, R.A.E., (2017) A combined approach using differential scanning calorimetry with polarized light thermomicroscopy in the investigation of ketoprofen and nicotinamide cocrystal, J. Therm. Anal. Calorim., 651, pp. 1-10.

DOI: 10.1016/j.tca.2017.02.014


Évora, A.O.L., Castro, R.A.E., Maria, T.M.R., Ramos Silva, M., ter Horst, J.H., Canotilho J., Eusébio, M.E.S., (2016) Co-crystals of diflunisal and isomeric pyridinecarboxamides - a thermodynamics and crystal engineering contribution, Cryst. Eng.Comm., 18, pp. 4749-4759.

DOI: 10.1039/c6ce00380j


Miranda, M.D., Chávez, F.V., Maria, T.M.R., Eusébio, M.E.S., Sebastião, P.J., Martín-Ramos, P., Figueirinhas, J.L., Ramos Silva, M., (2016) Synthesis of liquid crystals based on hydrogen-bonding of 4-(Octyloxy)benzoic acid with 4-alkylbenzoic acids, Mol. Cryst. Liq. Cryst., 630, pp. 87-101.

DOI: 10.1080/15421406.2016.1146881


Gallo, R.C., Ferreira, A.P.G., Castro, R.A.E., Cavalheiro, E.T.G., (2016) Studying the thermal decomposition of carvedilol by coupled TG-FTIR, J. Therm. Anal. Calorim., 123, pp. 2307-2312.



Sousa, A.F., Gandini, A., Caetano, A., Maria, T.M.R., Freire, C.S.R., Neto, C. P.l, Silvestre, A.J.D., (2016) Unravelling the distinct crystallinity and thermal properties of suberin compounds from Quercus suber and Betula pendula outer barks, Int. J. Biol. Macromol. 93, pp. 686-694.

DOI: 10.1016/j.ijbiomac.2016.09.031


Brandel, C., Cartigny, Y., Couvrat, N., Eusébio, M.E.S., Canotilho, J., Petit, S., Coquerel, G., (2015) Mechanisms of Reversible Phase Transitions in Molecular Crystals: Case of Ciclopirox, Chem. Mater., 27, pp. 6360-6373.

DOI: 10.1021/acs.chemmater.5b02389


Silva, P.S.P., Castro, R.A.E., Melro, E., Ramos Silva, M., Maria, T.M.R., Canotilho, J., Eusébio, M.E.S., (2015) Structural evidence of polymorphism and conformational isomorphism of a somewhat flexible molecule: m-anisic acid, J. Therm. Anal. Calorim., 120, pp. 667-677.

DOI: 10.1007/s10973-014-4289-y


Évora, A.O.L., Castro, R.A.E., Maria, T.M.R., Ramos Silva, M., ter Horst, J.H., Canotilho J., Eusébio, M.E.S., (2014) A thermodynamic based approach on the investigation of a diflunisal pharmaceutical co-crystal with improved intrinsic dissolution rate. Int. J. Pharm., 466, pp.67–74.

DOI: 10.1016/j.ijpharm.2014.02.048


Bebiano, S.V.S., Rosado, M.T.S., Castro, R.A.E., Ramos Silva, M., Canotilho, J., Maria, T.M.R., Eusébio, M.E.S., (2014) Polymorphism of cis-1,4-cyclohexanediol, a new plastic crystal former. Considerations on isomeric cyclohexanediols plastic crystal forming abilities, J. Mol. Struct., Polymorphism and Disorder issue, 1078, pp. 10-19.

DOI: 10.1016/j.molstruc.2014.02.008