Funded Projects

PTDC/QUI-OUT/29373/2017, “FightSterol – Alimentos que reduzem o colesterol“, 2018-2021.

PT2020-PTDC/DTP-FTO/2784/2014, “Unraveling the Rules of Passive Permeation Through the Blood-Brain Barrier”, 2016-2019.

P2020-PTDC/QEQ-MED/3521/2014, "Photoacoustic Permeabilization of Biological Barriers – A Window for Drug Delivery and Gene Transfection", 2016-2019.

Integrated action Luso-Espanhola E-07/12 , 2011-2012, “Bioavailability of amphiphilic Ligands – drugs and metabolites”.

PTDC/QUI/68242/2006, “Two-dimensional micelles and emulsions in lipid bilayers resulting from caophylic/caophobic amphiphilicity of some phospholipids. Biological consequences”, 2007-2011.

PTDC/SAU-FCF/69072/2006, “Quantitative modeling of Passive Trancytotic Diffusion of Amphiphilic Molecules Across the Blood-Brain Barrier”, 2007-2010. 

PTDC/QUI/64565/2006, “Molecular Crowding effects on the kinetics and thermodynamics of the interaction of amphiphilic molecules with proteins and with biological membranes”, 2008-2011. 

POCTI/QUI/45090/2002, “Structure, tropisms and molecular dynamics of the stratum corneum lipid matrix. A study in model systems”, 2003-2007.

POCTI/BCI/38861/2001, “Modeling biomembrane "rafts": characterization of the physical-chemical properties of lipid bilayer membranes with "raft"-like structures”, 2002-06.

High Performance Computing Projects

"HTRate: High-throughput strategy to calculate rate constants for drug/membrane systems" (PRACE Tier-1 project, deci14 call; 01/05/2017-30/04/2018; 9,800,000 standardised hours).

"Interaction of a homologous series of fluorescent probes with different lipid bilayers" (PRACE Tier-1 project, deci10 call; 01/05/2013-30/04/2014; 4,216,934 CPU hours).

"Estudo da localização e comportamento de ácidos biliares em bicamadas de POPC por dinâmica molecular" (Milipeia cluster, LCA-UC; 200,000 CPU hours; 19/01/2014-31/12/2014)

"Characterization of the frequency factor for the conversion from the transition state into the reaction products in lipid bilayers" (Milipeia cluster, LCA-UC; 150,000 CPU hours; 19/01/2014-31/12/2014)

2Estudo de bicamadas de lípidos com grupo polar invertido por simulação molecular2 (Milipeia cluster, LCA-UC; 150,000 CPU hours; 19/01/2014-31/12/2014)

"Interaction of fluorescent lipid probes NBD-diCnPE with different lipid bilayers"(Milipeia cluster, LCA-UC; 140,000 CPU hours; 01/11/2012-31/10/2013)

"Translocation and desorption reaction frequency of amphiphiles in POPC bilayers" (Milipeia cluster, LCA-UC; 140,000 CPU hours; 01/11/2012-31/10/2013)

"Potential of Mean Force calculation with different umbrella force constants" (Milipeia cluster, LCA-UC; 250,000 CPU hours; 1/11/2012-31/10/2013)

"Interaction of a homologous series of fluorescent probes with lipid bilayers" (Milipeia cluster, LCA-UC; 200,000 CPU hours; 1/11/2011-31/10/2012)