Selected Publications

C.F.G.C.Geraldes, M.Margarida C.A.Castro and J. Peters, (2022) Response to Letter to the Editors: ‘‘Have we lost an essential link between coordination chemistry and medical applications?”, Coordination Chemistry Reviews, 461, 214494 DOI: 10.1016/j.ccr.2022.214494

Rui F. S. Carvalho, Giovannia A. L. Pereira, João Rocha, M. Margarida C. A. Castro, Carlos M. Granadeiro, Helena I. S. Nogueira, Joop A. Peters, and Carlos F. G. C. Geraldes (2021) Lanthanopolyoxometalate-Silica Core/Shell Nanoparticles as Potential MRI Contrast Agents, Eur. J. Inorg. Chem., 3458-3465 DOI: 10.1002/ejic.202100445

Carlos F.G.C. Geraldes, M. Margarida C.A. Castro, Joop A. Peters (2021) Mn(III) porphyrins as potential MRI contrast agents for diagnosis and MRI-guided therapy, Coordination Chemistry Reviews, 445, 214069-214094 DOI: 10.1016/j.ccr.2021.214069

Vaz-Ramos, J., Cordeiro, R., Castro, M., Geraldes, C., Costa, B., Faneca, H., and Durães, L. (2020) Supercritically dried superparamagnetic mesoporous silica nanoparticles for cancer theranostics. Materials Science and Engineering: C 115, 111124 DOI: 10.1016/j.msec.2020.111124

Silva, F., Paulo, A., Pallier, A., Meme, S., Tóth, E., Gano, L., Marques, F., Geraldes, C. F. G. C., Castro, M. M. C. A., Cardoso, A. M., Jurado, A. S., Lopez-Larrubia, P., Lacerda, S., Campello, M. P. C. (2020) Dual imaging gold nanoplatforms for targeted radiotheranostics, Materials, 13, 513-530 DOI: 10.3390/ma13030513

Silva, F., Paulo, A., Pallier, A., Même, S., Tóth, E., Gano, L., Marques, Geraldes, F., C. F. G. C., Castro, M. M. C. A., Cardoso, A. M., Jurado, A. S., López-Larrubia, P., Lacerda, S., Cabral Campello, M. P. (2020) Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics, in Prime Archives in Material Science, 2nd Edition, Bogas, J. A., Ed., Vide Leaf, Hyderabad, India, ISBN: 978-93-90014-26-2.

Crans, D.C., Barkleyc, N.E., Montezinho L. and Castro, M.M.C.A., (2019) Vanadium Compounds as Enzyme Inhibitors with a Focus on Anticancer Effects. in Metal-based Anticancer Agents, Chapter 7, Metallobiology Series No. 14, Angela Casini, Anne Vessières and Samuel M. Meier-Menches Editors, The Royal Society of Chemistry, pp. 169-195, ISBN:978-1-78801-406-9 DOI: 10.1039/9781788016452-00348

Metelo, A., Arias-Ramos, N., Lopez-Larrubia, P., and Castro, M. (2019) Metabolic effects of VO(dmpp)2– anex vivo1H-HRMAS NMR study to unveil its pharmacological properties. New Journal of Chemistry 43, 17841-17849 DOI: 10.1039/C9NJ02491C

Pinto, S., Tomé, V., Calvete, M., Castro, M., Tóth, É., and Geraldes, C. (2019) Metal-based redox-responsive MRI contrast agents. Coordination Chemistry Reviews 390, 1-31 DOI: 10.1016/j.ccr.2019.03.014

Pinto, S., Calvete, M., Ghica, M., Soler, S., Gallardo, I., Pallier, A., Laranjo, M., Cardoso, A., Castro, M., Brett, C., Pereira, M., Tóth, É., and Geraldes, C. (2019) A biocompatible redox MRI probe based on a Mn(ii)/Mn(iii) porphyrin. Dalton Transactions 48, 3249-3262 DOI: 10.1039/C8DT04775H

Carvalho, J., Alves, S., Castro, M., Geraldes, C., Queiroz, J., Fonseca, C., and Cruz, C. (2019) Development of a bioreactor system for cytotoxic evaluation of pharmacological compounds in living cells using NMR spectroscopy. Journal of Pharmacological and Toxicological Methods 95, 70-78 DOI: 10.1016/j.vascn.2018.11.004

Morais, C., Cardoso, A., Cunha, P., Aguiar, L., Vale, N., Lage, E., Pinheiro, M., Nunes, C., Gomes, P., Reis, S., Castro, M., Pedroso de Lima, M., and Jurado, A. (2018) Acylation of the S413-PV cell-penetrating peptide as a means of enhancing its capacity to mediate nucleic acid delivery: Relevance of peptide/lipid interactions. Biochimica et Biophysica Acta (BBA) - Biomembranes 1860, 2619-2634 DOI: 10.1016/j.bbamem.2018.10.002

Calvete, M., Pinto, S., Burrows, H., Castro, M., Geraldes, C., and Pereira, M. (2020) Multifunctionalization of cyanuric chloride for the stepwise synthesis of potential multimodal imaging chemical entities. Arabian Journal of Chemistry 13, 2517-2525 DOI: 10.1016/j.arabjc.2018.06.005

Mariana P. Cabrera, Paulo E. Cabral Filho, Camila M. C. M. Silva, Rita M. Oliveira, Carlos F. G. C. Geraldes, M. Margarida C.A. Castro, Benilde F. O.  Costa, Marta S. C. Henriques, José A. Paixão, Luiz B. Carvalho Jr, Beate S. Santos, Fernando Hallwass, Adriana Fontes and Giovannia A. L. Pereira; Highly fluorescent and superparamagnetic nanosystem for biomedical applications, Nanotechnology 28, 285704 (2017). DOI: 10.1088/1361-6528/aa752a.

S.M.A.Pinto, V.A.Tomé,  M.J.F. Calvete, M.M.Pereira, H.D.Burrows, A.M.S.Cardoso, A. Pallier, M.M.C.A. Castro, É.Tóth, C.F.G.C Geraldes; The quest for biocompatible phthalocyanines for molecular imaging: Photophysics, relaxometry and cytotoxicity studies, J. Inorg. Biochem., 154, 50-59 (2016). DOI: 10.1016/j.jinorgbio.2015.10.013. 

Paulo E. Cabral Filho, Ana L.C. Cardoso, Maria I.A. Pereira, Ana P.M. Ramos, Fernando Hallwas, M. Margarida C.A. Castro, Carlos F.G.C. Geraldes, Beate S. Santos, Maria C. Pedroso de Lima, Giovannia A.L. Pereira, Adriana Fontes; CdTe quantum dots as fluorescent probes to study transferrin receptors in glioblastoma cells, Biochimica et Biophysica Acta, 1860, 28–35 (2016). DOI: 10.1016/j.bbagen.2015.09.021.  

Julien Pelletier, Neuza Domingues, M.Margarida C.A. Castro, Claes-Göran Östenson; In Vitro Effects of bis(1,2-dimethyl-3-hydroxy-4-pyridinonato)oxo-vanadium IV), or VO(dmpp)₂, on Insulin Secretion in Pancreatic Islets of Type 2 Diabetic Goto-Kakizaki Rats, J. Inorg. Biochem., 154, 29-34 (2016). DOI: 10.1016/j.jinorgbio.2015.11.004.

N. Domingues, J. Pelletier, C-G. Ostenson, M.M.C.A. Castro; Therapeutic properties of VO(dmpp)₂ as assessed by in vitro and in vivo studies in type 2 diabetic GK rats,J. Inorg. Biochem., 131, 115-122 (2014). DOI: 10.1016/j.jinorgbio.2013.11.005.

David M. Dias, João P. G. L. M. Rodrigues, Neuza S. Domingues,  Alexandre M. J. J. Bonvin and M. Margarida C. A. Castro; Unveiling the Interaction of Vanadium Compounds with Human Serum Albumin by Using ¹H STD NMR and Computational Docking Studies, Eur. J. Inorg. Chem., 2013, 4619-4627 (2013). DOI: 10.1002/ejic.201300419.

Gisela Gonçalves,   Isabel Tomaz,   Isabel Correia,  Luís F. Veiros,  M. Margarida C. A. Castro,   Fernando Avecilla, Lorena Palacio,   Miguel Maestro,   Tamás Kiss,  Tamás Jakusch,   M. Helena V. Garcia and  João Costa Pessoa; A novel VIVO–pyrimidinone complex: synthesis, solution speciation and human serum protein binding, Dalton Transactions, 42, 11841- 11861  (2013). DOI: 10.1039/C3DT50553G.

Carla P. Fonseca, Luís L. Fonseca, Liliana P. Montezinho, Paula M. Alves, Helena Santos, M. Margarida C. A. Castro, Carlos F. G. C. Geraldes; ²³Na multiple quantum filtered NMR characterisation of Na⁺ binding and dynamics in animal cells: a comparative study and effect of Na⁺/Li⁺ competition, Eur Biophys J.,  42, 503–519 (2013). DOI: 10.1007/s00249-013-0899-8.

 A. M. Metelo, R. Pérez - Carro, M. M. C. A. Castro and P. López-Larrubia; VO(dmpp)₂ normalizes pre-diabetic parameters as assessed by in vivo magnetic resonance imaging and spectroscopy, J. Inorg. Biochem., 115, 44-49 (2012). DOI: 10.1016/j.jinorgbio.2012.06.001.

Carla P. Fonseca, Liliana P. Montezinho and M. Margarida C.A.Castro; Lithium in Bipolar Disorder – possible mechanisms of its pharmacological mode of action In: Bipolar Disorder – a Portrait of a Complex Mood Disorder, In Tech Ed., online and printed Book, 2012, Chapter 4, pg. 57-98.

M. Passadouro, A.M. Metelo, A.S. Melão, J.R. Pedro, H. Faneca, E. Carvalho, M. M.C.A. Castro; Study of the antidiabetic capacity of the VO(dmpp)₂ complex, J. Inorg. Biochem.,104, 987-992 (2010). DOI: 10.1016/j.jinorgbio.2010.05.004.

 T.B. Rodrigues, C.P. Fonseca, M.M.C.A. Castro, S. Cerdán e C.F.G.C. Geraldes; ¹³C NMR tracers in neurochemistry: implications for molecular imaging, Quart. J. Nucl. Med. Mol. Imaging, 53, 631-645 (2009).

H. Faneca, V.A. Figueiredo, I. Tomaz, G. Gonçalves, F. Avecilla, M.C.P. de Lima, C.F.G.C. Geraldes, J.C. Pessoa e M.M.C.A. Castro; Vanadium compounds as therapeutic agents: some chemical and biochemical studies, J. Inorg. Biochem., 103, 601-608 (2009). DOI: 10.1016/j.jinorgbio.2008.11.004.

C.P. Fonseca, A. Sierra, C.F.G.C. Geraldes, M.M.C.A. Castro e S.Cerdán; Mechanisms underlying Li⁺ effects in glutamatergic and GABAergic neurotransmissions in the adult rat brain and in primary cultures of neural cells as revealed by ¹³C NMR, J. Neurosci. Res., 87, 1046-1055 (2009). DOI: 10.1002/jnr.21900.

T.C. Delgado, D. Pinheiro, M. Caldeira, M.M.C.A. Castro, C.F.G.C. Geraldes, P. López-Larrubia, S. Cerdán and J. G. Jones; Sources of hepatic triglyceride accumulation during high-fat feeding in the healthy  rat, NMR in Biomedicine, 22, 310-317 (2009). DOI: 10.1002/nbm.1327.

 T.C. Delgado, C. Barosa, M.M.C.A. Castro, C.F.G.C. Geraldes, M. Bastos, C. Baptista, A. Fagulha, L. Barros, A. Mota, M. Carvalheiro, J.G. Jones and M. Merritt; Sources of hepatic glucose production by ²H₂O ingestion and Bayesian analysis of 2H glucuronide enrichment, Magn. Reson. Med., 60, 517-523 (2008). DOI: 10.1002/mrm.21681.

B.G. Ramírez, T.B. Rodrigues, I.R. Violante, F. Cruz, L.L. Fonseca,  P. Ballesteros, M.M.C.A Castro, M.L. García-Martín e S. Cerdán; Kinetic properties of the redox switch/redox coupling mechanism as determined in primary cultures of cortical neurons and astrocytes from rat brain, J. Neurosc. Res., 85, 3244-3253 (2007). DOI: 10.1002/jnr.21386.

L.P. Montezinho, A. Mork, C.B. Duarte, S.Penschuck, C.F.G.C.Geraldes e M.M.C.A. Castro; Effect of mood stabilizers on dopamine D2-like receptors-mediated inhibition of adenylate cyclase, Bipolar Disorders, 9, 290-297 (2007). DOI: 10.1111/j.1399-5618.2007.00354.x.